Theres a few off the top of my head and they are:

Baker Bros, although theyve gotten quite big in terms of AUM that they have diversified to primary market placements. Range of biotech plays from small to large, hard to pinpoint an exact area they are focused on, but good track record nonetheless.

Broadfin Capital comes to mind, strong emphasis on small-mid cap medtech plays.

Perspective Advisors did well in 2015. From their holdings they appear focused on small-mid caps in niche disease areas with low clinical risk and unsaturated markets, something I personally like as well.

Dafna Capital, but they are relatively small in terms of AUM compared to the first 3. Also heavily weighted towards small caps niche market spaces.

Visium Asset Management, though theyve diversified and have exposure to more than just healthcare/biotech.

RA Capital has a very interesting, publicized research system and a teams built around pure life science backgrounds. Think financial models with a life science twist to it.

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Which venture funds are leading the healthcare/biotech space?

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Which venture funds are leading the healthcare/biotech space?

Which are the best discretionary hedge funds?